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A processing technology of two-photon microscopic image of nasopharyngeal cancer cells
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Paper Abstract

Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in china, with a deep and hidden localization. Recently, methods for early diagnosis of NPC has become one of the most important research topics in medical field. Early monitoring of morphological change of NPC cells during the carcinogenesis is of great importance, and early information extracted from the NPC cells during the initial stage of NPC is critical for diagnosis and treatment. In this paper, image processing methods for two-photon microscopic image of NPC cells was investigated with the purpose of providing useful information for early diagnosis and treatment of NPC. There is abundant information in a two-photon microscopic image of NPC cells, which can be analyzed and processed by means of computer and image pattern processing algorithm. In this paper, firstly, a mathematical method of transform of Bottom-hat based on Matlab platform was employed to enhance the image of NPC cells, making the image easier to distinguish; Then, several classical edge detection algorithms were compared and discussed, for example, Roberts operator, Prewitt operator, and Canny operator etc. According to the inherent characteristics of two-photon microscopic image of NPC cells, corrosion algorithm was used to define the edge of NPC cells. Furthermore, the article gets the iterative threshold segmentation after noise denoising, on the other hand, improved discriminant analysis was adopted for threshold segmentation of NPC cells, better results were obtained.

Paper Details

Date Published: 8 November 2010
PDF: 6 pages
Proc. SPIE 7845, Optics in Health Care and Biomedical Optics IV, 784529 (8 November 2010); doi: 10.1117/12.869806
Show Author Affiliations
Hongxin Lin, Fujian Normal Univ. (China)
Tingyin Wang, Fujian Normal Univ. (China)
Rong Chen, Fujian Normal Univ. (China)
Yanan Wu, Fujian Provincial Hospital (China)
Shangyuan Feng, Fujian Normal Univ. (China)
Zufang Huang, Fujian Normal Univ. (China)
Jinping Lei, Fujian Normal Univ. (China)
Lin Ou, Fujian Normal Univ. (China)
Guannan Chen, Fujian Normal Univ. (China)
Yongzeng Li, Fujian Normal Univ. (China)

Published in SPIE Proceedings Vol. 7845:
Optics in Health Care and Biomedical Optics IV
Qingming Luo; Ying Gu; Xingde Li, Editor(s)

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