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Proceedings Paper

Emerging fiber optic endomicroscopy technologies towards noninvasive real-time visualization of histology in situ
Author(s): Jiefeng Xi; Yuying Zhang; Li Huo; Yongping Chen; Toufic Jabbour; Ming-Jun Li; Xingde Li
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Paper Abstract

This paper reviews our recent developments of ultrathin fiber-optic endomicroscopy technologies for transforming high-resolution noninvasive optical imaging techniques to in vivo and clinical applications such as early disease detection and guidance of interventions. Specifically we describe an all-fiber-optic scanning endomicroscopy technology, which miniaturizes a conventional bench-top scanning laser microscope down to a flexible fiber-optic probe of a small footprint (i.e. ~2-2.5 mm in diameter), capable of performing two-photon fluorescence and second harmonic generation microscopy in real time. This technology aims to enable realtime visualization of histology in situ without the need for tissue removal. We will also present a balloon OCT endoscopy technology which permits high-resolution 3D imaging of the entire esophagus for detection of neoplasia, guidance of biopsy and assessment of therapeutic outcome. In addition we will discuss the development of functional polymeric fluorescent nanocapsules, which use only FAD approved materials and potentially enable fast track clinical translation of optical molecular imaging and targeted therapy.

Paper Details

Date Published: 8 September 2010
PDF: 5 pages
Proc. SPIE 7653, Fourth European Workshop on Optical Fibre Sensors, 765307 (8 September 2010); doi: 10.1117/12.867758
Show Author Affiliations
Jiefeng Xi, The Johns Hopkins Univ. (United States)
Yuying Zhang, The Johns Hopkins Univ. (United States)
Li Huo, The Johns Hopkins Univ. (United States)
Yongping Chen, The Johns Hopkins Univ. (United States)
Toufic Jabbour, The Johns Hopkins Univ. (United States)
Ming-Jun Li, Corning Inc. (United States)
Xingde Li, The Johns Hopkins Univ. (United States)


Published in SPIE Proceedings Vol. 7653:
Fourth European Workshop on Optical Fibre Sensors
José Luís Santos; Brian Culshaw; José Miguel López-Higuera; William N. MacPherson, Editor(s)

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