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Proceedings Paper

Novel reflectivity-difference biosensor
Author(s): Han Chen; Lian Wei; Ying Feng
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Paper Abstract

The traditional immobilized biomolecule detection technique on arrays has been fluorescence, but this has limitations because of its reliance on fluorophores. Alternatively, many label-free detection techniques have been developed such as surface plasmon resonance (SPR), ellipsometry, thin-film interference, diffractometry, and waveguides. These techniques have the advantage of high speed and high sensitivity, but in exchange rely on complicated structures or detailed sensing cells. A novel reflectivity-difference biosensor is introduced in this paper. When the sensor covered with a protein layer, the cells and the land would have opposite changes of the reflectance which lead to intensity shifts at the far-field diffraction plane. Therefore, it is convenient for the operation without intricate sensor structures and multifarious optical systems.

Paper Details

Date Published: 22 October 2010
PDF: 6 pages
Proc. SPIE 7658, 5th International Symposium on Advanced Optical Manufacturing and Testing Technologies: Optoelectronic Materials and Devices for Detector, Imager, Display, and Energy Conversion Technology, 76583G (22 October 2010); doi: 10.1117/12.865233
Show Author Affiliations
Han Chen, National Univ. of Defense Technology (China)
Lian Wei, National Univ. of Defense Technology (China)
Ying Feng, National Univ. of Defense Technology (China)


Published in SPIE Proceedings Vol. 7658:
5th International Symposium on Advanced Optical Manufacturing and Testing Technologies: Optoelectronic Materials and Devices for Detector, Imager, Display, and Energy Conversion Technology

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