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Proceedings Paper

Multiplexed detection of biological agents using optical microchip sensors
Author(s): D. Bhatta; M. B. McDonnell; E. Perkins
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Paper Abstract

A multi-channel optical microchip sensor system suitable for real-time, label-free detection of a wide range of biological agents is presented. SpectroSensTM chips containing multiple high-precision planar Bragg gratings are exploited as lowcost, robust refractive index sensors. Sensitivity to biological agents is conferred by functionalising individual sensing regions with different antibodies selected against numerous targets of interest. Antigen binding to the surfaceimmobilised antibodies results in localised changes in refractive index; upon laser-induced interrogation of the sensing region via optical fibres, these antibody-antigen interactions manifest as increases in wavelength of light reflected from the sensor chip. Real-time detection of multiple biological agents including bacterial cells/spores, viruses and toxins has been demonstrated. Further improvements to sensor performance including physical and chemical methods are also investigated. This multi-analyte capability highlights the potential use of this sensing technology in applications ranging from bio-hazard detection for defence purposes to point-of-care clinical diagnostics.

Paper Details

Date Published: 12 October 2010
PDF: 7 pages
Proc. SPIE 7838, Optics and Photonics for Counterterrorism and Crime Fighting VI and Optical Materials in Defence Systems Technology VII, 78380X (12 October 2010); doi: 10.1117/12.864842
Show Author Affiliations
D. Bhatta, Stratophase Ltd. (United Kingdom)
M. B. McDonnell, Defence Science and Technology Labs. (United Kingdom)
E. Perkins, Defence Science and Technology Labs. (United Kingdom)


Published in SPIE Proceedings Vol. 7838:
Optics and Photonics for Counterterrorism and Crime Fighting VI and Optical Materials in Defence Systems Technology VII
Colin Lewis; Doug Burgess; Roberto Zamboni; François Kajzar; Emily M. Heckman, Editor(s)

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