Share Email Print
cover

Proceedings Paper

Fabrication of Raman biochip prototype by femtosecond laser micromachining
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

In this work, a nanoscale surface-enhanced Raman scattering (SERS) substrate is fabricated by fs laser reduction and deposition. The conductive silver microstructures are also deposited in fs laser irradiated area on the glass surfaces. Based on this approach, we integrate the microelectronic circuit and micro-Raman substrate into a microfluidic chamber and form a prototype of Raman biochip for biosensing. Enhancement of Raman signal and control of temperature of the sensor are both achieved. This technique provides a great potential for integrating microelectronics and micro-Raman sensors on a single glass chip.

Paper Details

Date Published: 24 August 2010
PDF: 5 pages
Proc. SPIE 7759, Biosensing III, 775915 (24 August 2010); doi: 10.1117/12.864428
Show Author Affiliations
Zenghui Zhou, Shanghai Institute of Optics and Fine Mechanics (China)
Jian Xu, Shanghai Institute of Optics and Fine Mechanics (China)
Fei He, Shanghai Institute of Optics and Fine Mechanics (China)
Yang Liao, Shanghai Institute of Optics and Fine Mechanics (China)
Ya Cheng, Shanghai Institute of Optics and Fine Mechanics (China)
Zhizhan Xu, Shanghai Institute of Optics and Fine Mechanics (China)
Koji Sugioka, RIKEN (Japan)
Katsumi Midorikawa, RIKEN (Japan)


Published in SPIE Proceedings Vol. 7759:
Biosensing III
Hooman Mohseni; Manijeh Razeghi, Editor(s)

© SPIE. Terms of Use
Back to Top