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Proceedings Paper

Generation of micro- and nano-droplets containing immiscible solutions in view of optical studies
Author(s): V. Nastasa; T. Karapantsios; K. Samaras; E. Dafnopatidou; V. Pradines; R. Miller; M. L. Pascu
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Paper Abstract

The multiple resistances to treatment, developed by bacteria and malignant tumors require finding alternatives to the existing medicines and treatment procedures. One of them is strengthening the effects of cytostatics by improving the delivery method. Such a method is represented by the use of medicines as micro/nano-droplets. This method can reduce the substance consumption by generating drug micro-droplets incorporated in substances that can favour a faster localization, than the classical mode of medicine administration, to the tumor tissues. This paper contains the results concerning the generation and study of micro/nano-droplets and the generation of micro-droplets with an inner core (medicine) and a thin layer covering it. We have measured the surface tension at water/air interface and water/oil interface for a medicine (Vancomycin) and we have generated and measured droplets of medicine containing a layer of Vitamin A by using a double capillary system. The micro/nano-droplets may be produced by mixing of two immiscible solutions in particular conditions (high rotating speed and/or high pressure difference). For this we have studied the generation of emulsions of vitamin A diluted in sunflower oil and a solution of a surfactant Tween 80 in distilled water. The concentration of surfactant in water was typically 4*10-5M. We have studied in a batch stirred tank system the dependence of the droplet dimensions in emulsion, function of the mixing rotation speed, agitation time and components ratio. The droplet diameters were measured using a Malvern light scattering instrument type Mastersizer Hydro 2000M. We have obtained droplets with diameters smaller than 100 nm; the diameters distribution exhibited a peak at 65 nm.

Paper Details

Date Published: 30 August 2010
PDF: 7 pages
Proc. SPIE 7758, Physical Chemistry of Interfaces and Nanomaterials IX, 77580X (30 August 2010); doi: 10.1117/12.863824
Show Author Affiliations
V. Nastasa, National Institute for Lasers, Plasma and Radiation Physics (Romania)
T. Karapantsios, Aristolte Univ. of Thessaloniki (Greece)
K. Samaras, Aristolte Univ. of Thessaloniki (Greece)
E. Dafnopatidou, Aristolte Univ. of Thessaloniki (Greece)
V. Pradines, Max Planck Institute for Colloids and Interfaces (Germany)
R. Miller, Max Planck Institute for Colloids and Interfaces (Germany)
M. L. Pascu, National Institute for Lasers, Plasma and Radiation Physics (Romania)

Published in SPIE Proceedings Vol. 7758:
Physical Chemistry of Interfaces and Nanomaterials IX
Oleg V. Prezhdo, Editor(s)

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