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Proceedings Paper

SERS-based viral fingerprinting: current capabilities and challenges
Author(s): J. D. Driskell; J. L. Abell; R. A. Dluhy; Y.-P. Zhao; R. A. Tripp
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Paper Abstract

Silver nanorod array substrates are fabricated by oblique angle deposition and characterized for optimal SERS performance. Using UV-visible-NIR spectrophotometry we show that the nanorods have a transverse surface plasmon resonance mode at ~357 nm and a broad absorbance spanning 600-800 nm when excited along the longitudinal direction. We demonstrate that SERS enhancement is optimized using an excitation wavelength of 633 or 785 nm. The large area uniformity in SERS signal (<10% variation) and reproducibility among preparations (<15% variation) provides a unique opportunity for SERS-based whole-organism fingerprinting. Egg prepared avian influenza virus and clinical sputum samples of human influenza virus were investigated to demonstrate SERS-based detection of a virus in a complex sample matrix and to assess the effect of different background matrices on the detection of similar viruses.

Paper Details

Date Published: 13 April 2010
PDF: 10 pages
Proc. SPIE 7703, Independent Component Analyses, Wavelets, Neural Networks, Biosystems, and Nanoengineering VIII, 770303 (13 April 2010); doi: 10.1117/12.863616
Show Author Affiliations
J. D. Driskell, The Univ. of Georgia (United States)
J. L. Abell, The Univ. of Georgia (United States)
R. A. Dluhy, The Univ. of Georgia (United States)
Y.-P. Zhao, The Univ. of Georgia (United States)
R. A. Tripp, The Univ. of Georgia (United States)


Published in SPIE Proceedings Vol. 7703:
Independent Component Analyses, Wavelets, Neural Networks, Biosystems, and Nanoengineering VIII
Harold H. Szu; F. Jack Agee, Editor(s)

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