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Proceedings Paper

Radiative engineering of nanoantenna arrays for ultrasensitive vibrational spectroscopy of proteins
Author(s): Ronen Adato; Ahmet Ali Yanik; Jason J. Amsden; David L. Kaplan; Fiorenzo G. Omenetto; Mi Kyung Hong; Shyamsunder Erramilli; Hatice Altug
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Paper Abstract

Infrared absorption spectroscopy offers direct access to the vibrational signatures of molecular structure. Although absorption cross sections are nearly 10 orders of magnitude larger than the Raman cross sections, they are small in comparison with those of fluorescent labels. Sensitivity improvements are therefore required in order for the method to be applicable to single molecule/monolayer studies. In this work, we demonstrate a plasmon enhanced vibrational spectroscopy technique which allow for the measurement of molecule specific signatures at the monolayer level. Specifically, we show 4-5 order of magnitude enhancement of the amide-I and II backbone signature of protein monolayers, the signal resulting from only zeptomole quantities of molecules.

Paper Details

Date Published: 11 September 2010
PDF: 6 pages
Proc. SPIE 7757, Plasmonics: Metallic Nanostructures and Their Optical Properties VIII, 77571W (11 September 2010); doi: 10.1117/12.861031
Show Author Affiliations
Ronen Adato, Boston Univ. (United States)
Ahmet Ali Yanik, Boston Univ. (United States)
Jason J. Amsden, Tufts Univ. (United States)
David L. Kaplan, Tufts Univ. (United States)
Fiorenzo G. Omenetto, Tufts Univ. (United States)
Mi Kyung Hong, Boston Univ. (United States)
Shyamsunder Erramilli, Boston Univ. (United States)
Hatice Altug, Boston Univ. (United States)

Published in SPIE Proceedings Vol. 7757:
Plasmonics: Metallic Nanostructures and Their Optical Properties VIII
Mark I. Stockman, Editor(s)

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