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Proceedings Paper

Thermal and non-thermal intracellular mechanical fluctuations of living cells
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Paper Abstract

Intracellular stresses generated by molecular motors can actively modify cytoskeletal network, which causes changes in intracellular mechanical properties. We study the out-of-equilibrium microrheology in living cells. This paper reports measurements of the intracellular mechanical properties using passive and optical tweezers-based active microrheology approaches and endogenous organelle particles as probes. Using the fluctuation-dissipation theorem, we compared the two approaches measurements and distinguished thermal and non-thermal fluctuations of mechanical properties in living cells.

Paper Details

Date Published: 27 August 2010
PDF: 7 pages
Proc. SPIE 7762, Optical Trapping and Optical Micromanipulation VII, 77621L (27 August 2010); doi: 10.1117/12.860697
Show Author Affiliations
Ming-Tzo Wei, Lehigh Univ. (United States)
H. Daniel Ou-Yang, Lehigh Univ. (United States)

Published in SPIE Proceedings Vol. 7762:
Optical Trapping and Optical Micromanipulation VII
Kishan Dholakia; Gabriel C. Spalding, Editor(s)

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