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Proceedings Paper

Dynamic deformation of a soft particle in dual-trap optical tweezers
Author(s): Sebastien Rancourt-Grenier; Ming-Tzo Wei; Jar-Jin Bai; Arthur Chiou; Paul Bareil; Pierre-Luc Duval; Yunlong Sheng
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Paper Abstract

A dual-trap optical tweezers is used for deforming the red blood cell (RBC) in suspension and studying its elasticity. The radiation force is applied directly to the cell without physical contact. The 3D radiation stress distribution was computed by ray tracing, the generalized Lorentz-Mie theory with the T-matrix and the FDTD via the Maxwell stress tensor. The 3D deformation of the cells was computed with the elastic membrane theory. The calculated deformation can fit to experimental data resulting in cell's elasticity coefficient. The static approach is valid only for small deformation (5- 10%). For a large deformation such as that of the RBC, we consider re-distribution of the radiation stress on the morphologically deformed cell. This stress re-distribution in turn induces subsequent deformation of the deformed cell and new stress re-distribution. The recursive process continues until a final equilibrium state is achieved. This iterative computation was implemented with the finite element method using the COMSOLTM multi-physics models. The deformation results can fit to the experimental data for cell's deformation up to 20%.

Paper Details

Date Published: 28 August 2010
PDF: 8 pages
Proc. SPIE 7762, Optical Trapping and Optical Micromanipulation VII, 77621H (28 August 2010); doi: 10.1117/12.860262
Show Author Affiliations
Sebastien Rancourt-Grenier, Univ. Laval (Canada)
Ming-Tzo Wei, Lehigh Univ. (United States)
Jar-Jin Bai, National Yang-Ming Univ. (Taiwan)
Arthur Chiou, National Yang-Ming Univ. (Taiwan)
Paul Bareil, Univ. Laval (Canada)
Pierre-Luc Duval, Univ. Laval (Canada)
Yunlong Sheng, Univ. Laval (Canada)


Published in SPIE Proceedings Vol. 7762:
Optical Trapping and Optical Micromanipulation VII
Kishan Dholakia; Gabriel C. Spalding, Editor(s)

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