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Proceedings Paper

Luminescent conjugated oligothiophenes: optical dyes for revealing pathological hallmarks of protein misfolding diseases
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Paper Abstract

Luminescent conjugated polymers (LCPs) have been frequently utilized for optical biosensors. The detection schemes of these sensors are employing the light harvesting properties or the conformation sensitive optical properties of the conjugated polymers. LCPs have been utilized as colorimetric and fluorescent sensing elements for the recording of biological processes. However, LCPs have several limitations for being used as real time in vivo imaging agents. In this regard, novel thiophene based molecular scaffolds, denoted luminescent conjugated oligothiophenes (LCOs) have been developed. These LCOs are chemically defined molecules having distinct side chain functionalizations and a precise number of thiophene units. Herein the utilization of LCOs as specific ligands for the pathological hallmarks underlying protein misfolding diseases, such as Alzheimer's disease, is described. The use of the conformation sensitive optical properties of the LCOs for spectral separation of these pathological entities in a diversity of in vitro, ex vivo or in vivo systems is demonstrated. The protein aggregates are easily identified due to the conformation-dependent emission profile from the LCOs and spectral assignment of protein aggregates can be obtained. Overall, these probes will offer practical research tools for studying protein misfolding diseases and facilitate the study of the molecular mechanism underlying these disorders.

Paper Details

Date Published: 18 August 2010
PDF: 9 pages
Proc. SPIE 7779, Organic Semiconductors in Sensors and Bioelectronics III, 77790K (18 August 2010); doi: 10.1117/12.859808
Show Author Affiliations
Per Hammarström, Linköping Univ. (Sweden)
Mikael Lindgren, Linköping Univ. (Sweden)
Norwegian Univ. of Science and Technology (Norway)
K. Peter R. Nilsson, Linköping Univ. (Sweden)


Published in SPIE Proceedings Vol. 7779:
Organic Semiconductors in Sensors and Bioelectronics III
Ruth Shinar; Ioannis Kymissis, Editor(s)

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