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Proceedings Paper

Resolution of overlapping skin auto-fluorescence for development of non-invasive applications
Author(s): Yu-Zheng Su; Li-Wu Lin; Chuen-Yau Chen; Min-Wei Hung; Kuo-Cheng Huang
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Paper Abstract

Skin auto-fluorescence spectra can provide useful biological information, but the obtained spectrum is overlapped and is difficult to distinguish each contributed component. We applied the genetic algorithm to decompose the overlapping spectrum. First, we simulate the overlapping spectral to confirm our feasible algorithm. The skin auto-fluorescence spectra were obtained from the normal human skin with 337 nm excitation light source. The nicotinamide adenine dinucleotid (NADH) and flavin adenine dinucleotide (FAD) are accurately decomposed and demonstrated. The developed algorithm can be widely applied to achieve qualitative and quantitative analysis for overlapping spectra.

Paper Details

Date Published: 8 September 2010
PDF: 7 pages
Proc. SPIE 7797, Optics and Photonics for Information Processing IV, 77970Y (8 September 2010); doi: 10.1117/12.859094
Show Author Affiliations
Yu-Zheng Su, Instrument Technology Research Ctr. (Taiwan)
Li-Wu Lin, National Univ. of Kaohsiung (Taiwan)
Chuen-Yau Chen, National Univ. of Kaohsiung (Taiwan)
Min-Wei Hung, Instrument Technology Research Ctr. (Taiwan)
Kuo-Cheng Huang, Instrument Technology Research Ctr. (Taiwan)

Published in SPIE Proceedings Vol. 7797:
Optics and Photonics for Information Processing IV
Abdul Ahad Sami Awwal; Khan M. Iftekharuddin; Scott C. Burkhart, Editor(s)

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