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Proceedings Paper

Scheme for efficient fiber-based CARS probe
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Paper Abstract

We demonstrate a fiber-based probe for maximum collection of the Coherent anti-Stokes Raman Scattering (CARS) signal in biological tissues. We discuss the design challenges including capturing the back-scattered forward generated CARS signal in the sample and the effects of fiber nonlinearities on the propagating pulses. Three different biological tissues were imaged in vitro in order to assess the performance of our fiberdelivered probe for CARS imaging, a tool which we consider an important advance towards label-free, in vivo probing of superficial tissues.

Paper Details

Date Published: 26 February 2010
PDF: 6 pages
Proc. SPIE 7569, Multiphoton Microscopy in the Biomedical Sciences X, 75693A (26 February 2010); doi: 10.1117/12.855187
Show Author Affiliations
Mihaela Balu, Beckman Laser Institute and Medical Clinic (United States)
Gangjun Liu, Beckman Laser Institute and Medical Clinic (United States)
Zhongping Chen, Beckman Laser Institute and Medical Clinic (United States)
Univ. of California, Irvine (United States)
Bruce J. Tromberg, Beckman Laser Institute and Medical Clinic (United States)
Univ. of California, Irvine (United States)
Eric O. Potma, Beckman Laser Institute and Medical Clinic (United States)
Univ. of California, Irvine (United States)


Published in SPIE Proceedings Vol. 7569:
Multiphoton Microscopy in the Biomedical Sciences X
Ammasi Periasamy; Peter T. C. So; Karsten König, Editor(s)

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