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Proceedings Paper

Chemically responsive hydrogel with nanoparticle enhanced detection for small biomolecules
Author(s): Soame Banerji; Wei Peng; Yoon-Chang Kim; Karl S. Booksh
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Paper Abstract

A surface plasmon resonance (SPR) sensor to quantify glucose using a molecularly imprinted polymer was developed. The polymer was prepared by crosslinking poly(allylamine) in the presence of glucose phosphate, monobarium salt (GPS-Ba) and attached to a thin film of gold (50 nm) which had been sputtered on top of a glass slide, via amide coupling. Upon removal of the template, this sensor was used to detect glucose in human urine in physiologically significant levels (1-20 mg/ml). Signal enhancement of the glucose sensor was made possible by incorporating gold nanoparticles in the polymer.

Paper Details

Date Published: 24 April 2010
PDF: 11 pages
Proc. SPIE 7674, Smart Biomedical and Physiological Sensor Technologies VII, 76740A (24 April 2010); doi: 10.1117/12.854610
Show Author Affiliations
Soame Banerji, Univ. of Delaware (United States)
Wei Peng, Univ. of Delaware (United States)
Yoon-Chang Kim, Univ. of Delaware (United States)
Karl S. Booksh, Univ. of Delaware (United States)

Published in SPIE Proceedings Vol. 7674:
Smart Biomedical and Physiological Sensor Technologies VII
Brian M. Cullum; D. Marshall Porterfield; Karl S. Booksh, Editor(s)

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