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Proceedings Paper

Magnetic nanoparticle (MNP) enhanced biosensing by surface plasmon resonance (SPR) for portable devices
Author(s): Jianlong Wang; Zanzan Zhu; Ahsan Munir; H. Susan Zhou
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Paper Abstract

The use of magnetic nanparticles in microfluidic systems is emerging and is receiving growing attention due to the synergistic advantages of microfluidics and magnetic nanoparticles. Biomagnetic separation techniques based on magnetic nanoparticles are becoming increasingly important with a wide range of possible applications. However, the separation products are difficult to be detected by general method due to the small size of MNPs. Here, we demonstrate magnetic nanoparticles can greatly enhance the signal of surface plasmon resonance spectroscopy (SPR). Features of MNPs-aptamer conjugates as a powerful amplification reagent for ultrasensitive immunoassay are explored for the first time. Our results confirm that MNPs is a powerful sandwich element and an excellent amplification reagent for SPR based sandwich immunoassay and SPR has a great potential for the detection of magnetic nanoparticles-based separation products.

Paper Details

Date Published: 31 March 2010
PDF: 7 pages
Proc. SPIE 7647, Sensors and Smart Structures Technologies for Civil, Mechanical, and Aerospace Systems 2010, 76470T (31 March 2010); doi: 10.1117/12.854488
Show Author Affiliations
Jianlong Wang, Worcester Polytechnic Institute (United States)
Zanzan Zhu, Worcester Polytechnic Institute (United States)
Ahsan Munir, Worcester Polytechnic Institute (United States)
H. Susan Zhou, Worcester Polytechnic Institute (United States)

Published in SPIE Proceedings Vol. 7647:
Sensors and Smart Structures Technologies for Civil, Mechanical, and Aerospace Systems 2010
Masayoshi Tomizuka, Editor(s)

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