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Proceedings Paper

Photothermolysis of tumor with gold nanoparticles guided by NIR and acoustic thermometries
Author(s): Marina A. Sirotkina; Marina V. Shirmanova; Marina L. Bugrova; Ludmila B. Snopova; Vadim V. Elagin; Pavel V. Subochev; Vladislav A. Kamensky; Anatoly D. Mansfel'd; Victor A. Nadtochenko; Elena V. Zagainova
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Paper Abstract

In the current paper we present preliminary data demonstrating therapeutic efficiency of local laser hyperthermia of mouse tumors with gold nanoparticles. Measuring the tumor temperatures both superficial and inner by means of standard NIR-thermograph and original acoustic thermometer correspondingly we show that the gold nanoparticles increase thermal sensitivity of tumor tissue. Transmission electron microscopy and histopathology of the tumor tissue indicated that the mechanism of apoptotic death of tumor cells is triggered following the laser treatment. 5 days after the treatment tumor growth inhibition was 104 %.

Paper Details

Date Published: 17 May 2010
PDF: 7 pages
Proc. SPIE 7715, Biophotonics: Photonic Solutions for Better Health Care II, 77150R (17 May 2010); doi: 10.1117/12.854353
Show Author Affiliations
Marina A. Sirotkina, Nizhny Novgorod State Medical Academy (Russian Federation)
Marina V. Shirmanova, Nizhny Novgorod State Medical Academy (Russian Federation)
Marina L. Bugrova, Nizhny Novgorod State Medical Academy (Russian Federation)
Ludmila B. Snopova, Nizhny Novgorod State Medical Academy (Russian Federation)
Vadim V. Elagin, Nizhny Novgorod State Medical Academy (Russian Federation)
Pavel V. Subochev, Institute of Applied Physics (Russian Federation)
Vladislav A. Kamensky, Institute of Applied Physics (Russian Federation)
Anatoly D. Mansfel'd, Institute of Applied Physics (Russian Federation)
Victor A. Nadtochenko, Institute of Problems of Chemical Physics (Russian Federation)
Elena V. Zagainova, Nizhny Novgorod State Medical Academy (Russian Federation)


Published in SPIE Proceedings Vol. 7715:
Biophotonics: Photonic Solutions for Better Health Care II
Jürgen Popp; Wolfgang Drexler; Valery V. Tuchin; Dennis L. Matthews, Editor(s)

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