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Proceedings Paper

Biconical tapered optical fiber biosensor for measuring refractive index of a-amino acids in aqueous D-glucose and sucrose solution
Author(s): M. I. Zibaii; H. Latifi; M. Karami; M. Gholami; S. M. Hosseini; M. H. Ghezelayagh
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Paper Abstract

A single-mode biconical tapered optical fiber (BTOF) sensor was utilized for sensing the variation of refractive index (RI) with concentration of D-glucose in double distilled deionized water and measuring of RI of amino acids (AAs) in carbohydrate solutions. This method showed a rewarding ability in understanding the basis of biomolecular interactions in biological systems. The BTOF is fabricated by heat pulling method, utilizing a CO2 laser. The detection limit of the BTOF was 50 ppb for the D-glucose concentration ranging from 0 to 80 ppm, and RI detection limit corresponding to these concentrations in the range at 1.3333 to 1.3404 was 5.4×10-6 as a refractometer sensor. The response of the BTOF shows that the different kinds of interactions of various groups of AAs such as L-alanine, L-leucine, and L-cystein with D-glucose, sucrose and water molecules depend on functional groups in AAs such as OH, SH;CH2;NH3+ ,COO-. These results can be interpreted in terms of solute-solute and solute-solvent interactions and structure making/breaking ability of solutes in the given solution.

Paper Details

Date Published: 18 May 2010
PDF: 11 pages
Proc. SPIE 7715, Biophotonics: Photonic Solutions for Better Health Care II, 77151Y (18 May 2010); doi: 10.1117/12.853969
Show Author Affiliations
M. I. Zibaii, Shahid Beheshti Univ. (Iran, Islamic Republic of)
H. Latifi, Shahid Beheshti Univ. (Iran, Islamic Republic of)
M. Karami, Shahid Beheshti Univ. (Iran, Islamic Republic of)
M. Gholami, Shahid Beheshti Univ. (Iran, Islamic Republic of)
S. M. Hosseini, Shahid Beheshti Univ. (Iran, Islamic Republic of)
M. H. Ghezelayagh, Shahid Beheshti Univ. (Iran, Islamic Republic of)


Published in SPIE Proceedings Vol. 7715:
Biophotonics: Photonic Solutions for Better Health Care II
Jürgen Popp; Wolfgang Drexler; Valery V. Tuchin; Dennis L. Matthews, Editor(s)

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