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Proceedings Paper

Analytic modeling of antibody versus nanocell delivery of photosensitizer
Author(s): Brian W. Pogue; Subhadra Srinivasan; Kimberley Samkoe; Lei Zak Zheng; Prakash Rai; Zhiming Mai; Sarika Verma; Tayyaba Hasan
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Paper Abstract

Delivery of therapeutic agents to solid tumors is challenging, and the issues that govern this can be distilled down into parameters which allow computational modeling. In this paper, the basic rate equations and diffusion kernel for the time and space modeling of delivery are developed, along with an analytical solution to this equation. The model is then used to compare delivery of Avastin antibody relative to delivery encapsulated in a nanocell delivery vehicle. The key factors are the plasma clearance or excretion rates, and the binding, or not, as it transports into the tumor tissue. A reduction in the plasma clearance rate inherently increases available delivery over time, and additionally the reduction in binding from antibody to nanocell allows higher penetration into the tumor at the longer circulation times.

Paper Details

Date Published: 2 March 2010
PDF: 8 pages
Proc. SPIE 7551, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIX, 755117 (2 March 2010); doi: 10.1117/12.853925
Show Author Affiliations
Brian W. Pogue, Dartmouth College (United States)
Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)
Subhadra Srinivasan, Dartmouth College (United States)
Kimberley Samkoe, Dartmouth College (United States)
Lei Zak Zheng, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)
Prakash Rai, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)
Zhiming Mai, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)
Sarika Verma, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)
Tayyaba Hasan, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)


Published in SPIE Proceedings Vol. 7551:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIX
David H. Kessel, Editor(s)

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