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Proceedings Paper

Mechanical compression for biotissue image enhancement in optical coherence tomography
Author(s): P. D. Agrba; M. Yu. Kirillin; A. I. Abelevich; V. A. Kamensky
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Paper Abstract

The paper discusses application of mechanical compression for contrasting structural components of biotissues with different mechanical properties in optical coherence tomography (OCT) images. Ex vivo study on human rectum samples and in vivo study on human thin skin samples are performed. It is shown that for ex vivo sample the contrast between epithelial and stroma layers increases with increase in applied pressure. For in vivo sample it is shown that at weak constant applied pressure the contrast between epidermal and dermal layer increases exhibiting maximum after 2-3 minutes since pressure application. Monte Carlo simulations of OCT images of human rectum sample at different compression levels is performed in order to confirm the origin of contrast. The results of simulations qualitatively agree with experimental data.

Paper Details

Date Published: 11 February 2010
PDF: 7 pages
Proc. SPIE 7547, Saratov Fall Meeting 2009: International School for Junior Scientists and Students on Optics, Laser Physics, and Biophotonics, 754703 (11 February 2010); doi: 10.1117/12.853436
Show Author Affiliations
P. D. Agrba, N.I. Lobachevsky State Univ. of Nizhny Novgorod (Russian Federation)
Institute of Applied Physics (Russian Federation)
M. Yu. Kirillin, Institute of Applied Physics (Russian Federation)
A. I. Abelevich, Nizhny Novgorod State Medical Academy (Russian Federation)
V. A. Kamensky, Institute of Applied Physics (Russian Federation)


Published in SPIE Proceedings Vol. 7547:
Saratov Fall Meeting 2009: International School for Junior Scientists and Students on Optics, Laser Physics, and Biophotonics
Valery V. Tuchin; Elina A. Genina, Editor(s)

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