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Proceedings Paper

Imaging osteoarthritis in the knee joints using x-ray guided diffuse optical tomography
Author(s): Qizhi Zhang; Zhen Yuan; Eric S. Sobel; Huabei Jiang
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Paper Abstract

In our previous studies, near-infrared (NIR) diffuse optical tomography (DOT) had been successfully applied to imaging osteoarthritis (OA) in the finger joints where significant difference in optical properties of the joint tissues was evident between healthy and OA finger joints. Here we report for the first time that large joints such as the knee can also be optically imaged especially when DOT is combined with x-ray tomosynthesis where the 3D image of the bones from x-ray is incorporated into the DOT reconstruction as spatial a priori structural information. This study demonstrates that NIR light can image large joints such as the knee in addition to finger joints, which will drastically broaden the clinical utility of our x-ray guided DOT technique for OA diagnosis.

Paper Details

Date Published: 2 March 2010
PDF: 4 pages
Proc. SPIE 7548, Photonic Therapeutics and Diagnostics VI, 75484J (2 March 2010); doi: 10.1117/12.853402
Show Author Affiliations
Qizhi Zhang, Univ. of Florida (United States)
Zhen Yuan, Univ. of Florida (United States)
Eric S. Sobel, College of Medicine, Univ. of Florida (United States)
Huabei Jiang, Univ. of Florida (United States)


Published in SPIE Proceedings Vol. 7548:
Photonic Therapeutics and Diagnostics VI
Anita Mahadevan-Jansen; Andreas Mandelis; Brian Jet-Fei Wong; Nikiforos Kollias; Henry Hirschberg; Kenton W. Gregory; Reza S. Malek; E. Duco Jansen; Guillermo J. Tearney; Steen J. Madsen; Bernard Choi; Justus F. R. Ilgner; Haishan Zeng; Laura Marcu, Editor(s)

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