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Proceedings Paper

Quantum dots in life sciences: applications, benefits, and safety issues
Author(s): James B. Delehanty; Christopher E. Bradburne; Kelly Boeneman; Kimihiro Susumu; Bing C. Mei; Juan B. Blanco-Canosa; Phillip E. Dawson; Hedi Mattoussi; Alan Huston; Igor L. Medintz
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Paper Abstract

Luminescent semiconductor quantum dots (QDs) possess several unique optical and spectroscopic properties including high quantum yields, broad absorption spectra coupled to narrow symmetric, size-tunable emissions allowing large achievable Stokes shifts, and exceptional resistance to photo- and chemical degradation. These properties make QDs unique enabling materials for the development of the next generation of highly efficient biosensors for health security applications, particularly within the context of living and fixed cells. Paramount in this developmental process is addressing the biocompatibility of the QD materials. We are developing robust and facile delivery schemes for the selective intracellular delivery of QD-based nanoassemblies. These schemes are based upon the self-assembly and subsequent cellular uptake of QD-peptide and QD-polymer bioconjugates. Cellular delivery experiments utilizing both delivery schemes will be presented. The advantages and disadvantages of each approach will be discussed, including the intracellular fate and stability of the QD-nanoassemblies.

Paper Details

Date Published: 5 May 2010
PDF: 6 pages
Proc. SPIE 7666, Sensors, and Command, Control, Communications, and Intelligence (C3I) Technologies for Homeland Security and Homeland Defense IX, 766619 (5 May 2010); doi: 10.1117/12.853121
Show Author Affiliations
James B. Delehanty, U.S. Naval Research Lab. (United States)
Christopher E. Bradburne, U.S. Naval Research Lab. (United States)
Kelly Boeneman, U.S. Naval Research Lab. (United States)
Kimihiro Susumu, U.S. Naval Research Lab. (United States)
Bing C. Mei, U.S. Naval Research Lab. (United States)
Juan B. Blanco-Canosa, The Scripps Research Institute (United States)
Phillip E. Dawson, The Scripps Research Institute (United States)
Hedi Mattoussi, U.S. Naval Research Lab. (United States)
Alan Huston, U.S. Naval Research Lab. (United States)
Igor L. Medintz, U.S. Naval Research Lab. (United States)


Published in SPIE Proceedings Vol. 7666:
Sensors, and Command, Control, Communications, and Intelligence (C3I) Technologies for Homeland Security and Homeland Defense IX
Edward M. Carapezza, Editor(s)

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