Share Email Print
cover

Proceedings Paper

Label-free detection of biomolecules using a tapered optical fiber sensor
Author(s): Ye Tian; Wenhui Wang; Armand Chery; Nan Wu; Charles Guthy; Xingwei Wang
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

A tapered optical fiber sensor (TOFS) is a kind of optical fiber sensor that uses special geometries to measure properties of surrounding environments or samples using evanescent waves. This paper presents a fast, highly sensitive, and inexpensive tapered optical fiber biosensor that, using a miniature sensing structure, enables the label-free direct detection of biomolecules. The sensor takes advantage of the interference effect between the fiber's first two modes along the taper waist region. This effect causes some interference fringes in the transmission spectrum. Because of its sharp spectrum fringe signals and its long biomolecule testing region, the sensor is fast and highly sensitive. To better understand the influence of various biomolecules on the sensor, a computer simulation that varied such bio-layer parameters as thickness and refractive index was performed. The result of 0.4 nm/nm showed that the spectrum fringe shift of the sensor was large enough to be easily measured even when the bio-layer was nanometers thick. A tapered optical fiber biosensor was then fabricated and evaluated with an immune globulin G (IgG) antibody-antigen pair, and showed good performance.

Paper Details

Date Published: 27 April 2010
PDF: 7 pages
Proc. SPIE 7673, Advanced Environmental, Chemical, and Biological Sensing Technologies VII, 767307 (27 April 2010); doi: 10.1117/12.852215
Show Author Affiliations
Ye Tian, Univ. of Massachusetts Lowell (United States)
Wenhui Wang, Univ. of Massachusetts Lowell (United States)
Armand Chery, Univ. of Massachusetts Lowell (United States)
Nan Wu, Univ. of Massachusetts Lowell (United States)
Charles Guthy, Univ. of Massachusetts Lowell (United States)
Xingwei Wang, Univ. of Massachusetts Lowell (United States)


Published in SPIE Proceedings Vol. 7673:
Advanced Environmental, Chemical, and Biological Sensing Technologies VII
Tuan Vo-Dinh; Robert A. Lieberman; Günter Gauglitz, Editor(s)

© SPIE. Terms of Use
Back to Top