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Proceedings Paper

Photonic materials for encoding and detection of biomolecules
Author(s): Yuanjin Zhao; Xiangwei Zhao; Zhongze Gu
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Paper Abstract

Multiplex assays have attracted considerable interest to meet the growing demand for clinical diagnosis, gene expression, drug discovery, and so on. Most of the assays are based on molecular binding or recognition events. In this point, different probe biomolecules could be immobilized to encoded carriers, which can be mixed and subjected to an assay simultaneously and then many binding events can be distinguished by their codes. Herein we summarize our work on photonic beads as novel encoded carriers of biomolecules in multiplex bioassays. We have successfully fabricated different kinds of encoded photonic beads with controlled size and monodispersity by microfluidic device. The beads with opal structure and inverse opal structure could be used in multiplex labeling detection and label-free detection of biomolecules, respectively. These photonic beads provide a new coding strategy of suspension array for low cost, sensitive and simultaneous multiplex bioassay.

Paper Details

Date Published: 21 April 2010
PDF: 9 pages
Proc. SPIE 7682, Photonic Microdevices/Microstructures for Sensing II, 768203 (21 April 2010); doi: 10.1117/12.850964
Show Author Affiliations
Yuanjin Zhao, Southeast Univ. (China)
Xiangwei Zhao, Southeast Univ. (China)
Zhongze Gu, Southeast Univ. (China)
Suzhou Research Institute of Southeast Univ. (China)

Published in SPIE Proceedings Vol. 7682:
Photonic Microdevices/Microstructures for Sensing II
Xudong Fan; Hai Xiao; Anbo Wang, Editor(s)

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