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Proceedings Paper

Targeted in-vivo computed tomography (CT) imaging of tissue ACE using concentrated lisinopril-capped gold nanoparticle solutions
Author(s): Marie-Christine Daniel; Omer Aras; Mark F. Smith; Anjan Nan; Thorsten Fleiter
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Paper Abstract

The development of cardiac and pulmonary fibrosis have been associated with overexpression of angiotensin-converting enzyme (ACE). Moreover, ACE inhibitors, such as lisinopril, have shown a benificial effect for patients diagnosed with heart failure or systemic hypertension. Thus targeted imaging of the ACE is of crucial importance for monitoring of the tissue ACE activity as well as the treatment efficacy in heart failure. In this respect, lisinopril-capped gold nanoparticles were prepared to provide a new type of probe for targeted molecular imaging of ACE by tuned K-edge computed tomography (CT) imaging. Concentrated solutions of these modified gold nanoparticles, with a diameter around 16 nm, showed high contrast in CT imaging. These new targeted imaging agents were thus used for in vivo imaging on rat models.

Paper Details

Date Published: 24 April 2010
PDF: 9 pages
Proc. SPIE 7674, Smart Biomedical and Physiological Sensor Technologies VII, 76740J (24 April 2010); doi: 10.1117/12.849841
Show Author Affiliations
Marie-Christine Daniel, Univ. of Maryland, Baltimore County (United States)
Omer Aras, Univ. of Maryland Hospital and School of Medicine (United States)
Mark F. Smith, Univ. of Maryland Hospital and School of Medicine (United States)
Anjan Nan, Univ. of Maryland School of Pharmacy (United States)
Thorsten Fleiter, Univ. of Maryland Hospital and School of Medicine (United States)


Published in SPIE Proceedings Vol. 7674:
Smart Biomedical and Physiological Sensor Technologies VII
Brian M. Cullum; D. Marshall Porterfield; Karl S. Booksh, Editor(s)

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