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Proceedings Paper

Strategies for developing pH sensitive fluorescent probes
Author(s): Mikhail Y. Berezin; Kevin Guo; Hyeran Lee; Walter Akers; Adah Almutairi; Jean M. J. Fréchet; Samuel Achilefu
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Paper Abstract

Many physiological processes function efficiently within a well-controlled pH range. Higher acidity level has been implicated with a number of systemic pathologies. The potential of pH sensitive fluorescent probes for reporting on biological environments has been widely utilized in a variety of cell studies and has been recently recognized as a powerful technique for in vivo imaging of diseases associated with elevated acidity level. We present several strategies for the development of pH sensitive probes suitable for in vivo imaging. The strategies include incorporation of pH sensitive functionalities in known fluorophores, synthesis of novel pH sensitive skeletons, and design of pH sensitive nanoparticles using acid-degradable polymers.

Paper Details

Date Published: 16 February 2010
PDF: 8 pages
Proc. SPIE 7576, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II, 75760F (16 February 2010); doi: 10.1117/12.849452
Show Author Affiliations
Mikhail Y. Berezin, Washington Univ. School of Medicine in St. Louis (United States)
Kevin Guo, Washington Univ. School of Medicine in St. Louis (United States)
Hyeran Lee, Washington Univ. School of Medicine in St. Louis (United States)
Walter Akers, Washington Univ. School of Medicine in St. Louis (United States)
Adah Almutairi, Univ. of California, Berkeley (United States)
Jean M. J. Fréchet, Univ. of California, Berkeley (United States)
Samuel Achilefu, Washington Univ. School of Medicine in St. Louis (United States)


Published in SPIE Proceedings Vol. 7576:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

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