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Proceedings Paper

Fat tissue staining and photodynamic/photothermal effects
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Paper Abstract

Cellulite is considered as a disease of the subcutaneous fat layer that appears mostly in women and consists of changes in fat cell accumulation together with disturbed lymphatic drainage, affecting the external appearance of the skin. The photodynamic and selective photothermal treatments may provide reduction the volume of regional or sitespecific accumulations of subcutaneous adipose tissue on the cellular level. We hypothesize that light irradiation of stained fat tissue at selected temperature leads to fat cell lypolytic activity (the enhancement of lipolysis of cell triglycerides due to expression of lipase activity and cell release of free fat acids (FFAs) due to temporal cell membrane porosity), and cell killing due to apoptosis caused by the induced fat cell stress and/or limited cell necrosis.

Paper Details

Date Published: 25 February 2010
PDF: 7 pages
Proc. SPIE 7563, Dynamics and Fluctuations in Biomedical Photonics VII, 75630V (25 February 2010); doi: 10.1117/12.849346
Show Author Affiliations
Valery V. Tuchin, Saratov State Univ. (Russian Federation)
Institute of Precise Mechanics and Control (Russian Federation)
Gregory B. Altshuler, Palomar Medical Technologies, Inc. (United States)
Irina Yu. Yanina, Saratov State Univ. (Russian Federation)
Vyacheslav I. Kochubey, Saratov State Univ. (Russian Federation)
Georgy V. Simonenko, Saratov State Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 7563:
Dynamics and Fluctuations in Biomedical Photonics VII
Valery V. Tuchin; Donald D. Duncan; Kirill V. Larin, Editor(s)

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