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Proceedings Paper

RF hyperthermia using conductive nanoparticles
Author(s): H. Michael Gach; Arvind Balachandrasekaran; Tejas Nair
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Paper Abstract

Specific absorption rate (SAR) heating using radiofrequency (RF) waves is affected by the RF frequency and amplitude, and the conductivity of the tissue. Recently, conductive nanoparticles were demonstrated to induce hyperthermia in vitro and in vivo upon irradiation with an external 13.56 MHz RF field. The addition of conductive nanoparticles was assumed to increase the tissue conductivity and SAR. However, no quantitative studies have been performed that characterize the conductivities of biocompatible colloids or tissues containing nanoparticles, and relate the conductivity to SAR. The complex permittivities were measured for colloids containing single-wall carbon nanotubes (SWCNTs) in normal saline with 0.32% w/v Pluronic F108 nonionic surfactant. The carbon concentrations of the colloids ranged from 0 to 88 mM. The permittivities were measured using a dielectric probe and RF network analyzer for RF frequencies from 200 MHz to 3 GHz. The nonionic surfactant was added to the colloids to minimize flocculation of the nanotubes during the RF heating experiments. The results were compared with prior measurements of colloids containing 0.02% Pluronic F108. The dielectric and conductivity of the 0.02% Pluronic colloids rose linearly with carbon concentration but the 0.32% Pluronic colloids varied from linearity. Based on the permittivity results, selected colloid samples were placed inside a Bruker 7T/20 magnetic resonance (MR) imaging (MRI) system and irradiated at 300 MHz using a high duty cycle RF pulse sequence. The temperature changes were measured directly using fiber-optic thermometers and indirectly using MR thermometry and spectroscopy. Temperature changes were consistent with the colloid conductivities.

Paper Details

Date Published: 2 March 2010
PDF: 11 pages
Proc. SPIE 7548, Photonic Therapeutics and Diagnostics VI, 754841 (2 March 2010); doi: 10.1117/12.848627
Show Author Affiliations
H. Michael Gach, Nevada Cancer Institute (United States)
Univ. of Nevada Las Vegas (United States)
Univ. of Nevada School of Medicine (United States)
Arvind Balachandrasekaran, Nevada Cancer Institute (United States)
Tejas Nair, Nevada Cancer Institute (United States)

Published in SPIE Proceedings Vol. 7548:
Photonic Therapeutics and Diagnostics VI
Anita Mahadevan-Jansen; Andreas Mandelis; Brian Jet-Fei Wong M.D.; Nikiforos Kollias; Henry Hirschberg M.D.; Kenton W. Gregory M.D.; Reza S. Malek; E. Duco Jansen; Guillermo J. Tearney; Steen J. Madsen; Bernard Choi; Justus F. R. Ilgner; Haishan Zeng; Laura Marcu, Editor(s)

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