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Proceedings Paper

Three-dimensional dynamics of temperature fields in phantoms and biotissue under IR laser photothermal therapy using gold nanoparticles and ICG dye
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Paper Abstract

We describe applications of silica (core)/gold (shell) nanoparticles and ICG dye to photothermal treatment of phantoms, biotissue and spontaneous tumor of cats and dogs. The laser irradiation parameters were optimized by preliminary experiments with laboratory rats. Three dimensional dynamics of temperature fields in tissue and solution samples was measured with a thermal imaging system. It is shown that the temperature in the volume region of nanoparticles localization can substantially exceed the surface temperature recorded by the thermal imaging system. We have demonstrated effective optical destruction of cancer cells by local injection of plasmon-resonant gold nanoshells and ICG dye followed by continuous wave (CW) diode laser irradiation at wavelength 808 nm.

Paper Details

Date Published: 26 February 2010
PDF: 8 pages
Proc. SPIE 7563, Dynamics and Fluctuations in Biomedical Photonics VII, 75630M (26 February 2010); doi: 10.1117/12.848554
Show Author Affiliations
Georgy G Akchurin, Saratov State Univ. (Russian Federation)
Institute of Precise Mechanics and Control (Russian Federation)
Akchurin G. Garif, Saratov State Univ. (Russian Federation)
Institute of Precise Mechanics and Control (Russian Federation)
Irina L. Maksimova, Saratov State Univ. (Russian Federation)
Alexander A. Skaptsov, Saratov State Univ. (Russian Federation)
Georgy S. Terentyuk, First Veterinary Clinic (Russian Federation)
Boris N. Khlebtsov, Saratov State Univ. (Russian Federation)
Institute of Biochemistry and Physiology of Plants and Microorganisms (Russian Federation)
Nikolai G. Khlebtsov, Saratov State Univ. (Russian Federation)
Institute of Biochemistry and Physiology of Plants and Microorganisms (Russian Federation)
Valery V. Tuchin, Saratov State Univ. (Russian Federation)
Institute of Precise Mechanics and Control (Russian Federation)


Published in SPIE Proceedings Vol. 7563:
Dynamics and Fluctuations in Biomedical Photonics VII
Valery V. Tuchin; Donald D. Duncan; Kirill V. Larin, Editor(s)

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