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Proceedings Paper

Targeted delivery of cancer-specific multimodal contrast agents for intraoperative detection of tumor boundaries and therapeutic margins
Author(s): Ronald X. Xu; Jeff S. Xu; Jiwei Huang; Michael F. Tweedle; Carl Schmidt; Stephen P. Povoski; Edward W. Martin
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Paper Abstract

Background: Accurate assessment of tumor boundaries and intraoperative detection of therapeutic margins are important oncologic principles for minimal recurrence rates and improved long-term outcomes. However, many existing cancer imaging tools are based on preoperative image acquisition and do not provide real-time intraoperative information that supports critical decision-making in the operating room. Method: Poly lactic-co-glycolic acid (PLGA) microbubbles (MBs) and nanobubbles (NBs) were synthesized by a modified double emulsion method. The MB and NB surfaces were conjugated with CC49 antibody to target TAG-72 antigen, a human glycoprotein complex expressed in many epithelial-derived cancers. Multiple imaging agents were encapsulated in MBs and NBs for multimodal imaging. Both one-step and multi-step cancer targeting strategies were explored. Active MBs/NBs were also fabricated for therapeutic margin assessment in cancer ablation therapies. Results: The multimodal contrast agents and the cancer-targeting strategies were tested on tissue simulating phantoms, LS174 colon cancer cell cultures, and cancer xenograft nude mice. Concurrent multimodal imaging was demonstrated using fluorescence and ultrasound imaging modalities. Technical feasibility of using active MBs and portable imaging tools such as ultrasound for intraoperative therapeutic margin assessment was demonstrated in a biological tissue model. Conclusion: The cancer-specific multimodal contrast agents described in this paper have the potential for intraoperative detection of tumor boundaries and therapeutic margins.

Paper Details

Date Published: 23 February 2010
PDF: 7 pages
Proc. SPIE 7556, Design and Quality for Biomedical Technologies III, 75560T (23 February 2010); doi: 10.1117/12.848299
Show Author Affiliations
Ronald X. Xu, The Ohio State Univ. (United States)
Jeff S. Xu, The Ohio State Univ. (United States)
Jiwei Huang, The Ohio State Univ. (United States)
Michael F. Tweedle, The Ohio State Univ. (United States)
Carl Schmidt, The Ohio State Univ. (United States)
Stephen P. Povoski, The Ohio State Univ. (United States)
Edward W. Martin, The Ohio State Univ. (United States)


Published in SPIE Proceedings Vol. 7556:
Design and Quality for Biomedical Technologies III
Ramesh Raghavachari; Rongguang Liang, Editor(s)

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