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Proceedings Paper

Systematic approach to study of thinly and thickly sectioned melanoma tissues with scanning acoustic microscopy
Author(s): C. Miyasaka; B. R. Tittmann; R. Tutwiler; Y. Tian; E. Maeva; D. Shum
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Paper Abstract

The present study is to investigate the feasibility of applying in-vivo acoustic microscopy to the analysis of cancerous tissue. The study was implemented with mechanical scanning reflection acoustic microscope (SAM) by the following procedures. First, we ultrasonically visualized thick sections of normal and tumor tissues to determine the lowest transducer frequency required for cellular imaging. We used skin for normal tissue and the tumor was a malignant melanoma. Thin sections of the tissue were also studied with the optical and high-frequency-ultrasonic imaging for pathological evaluation. Secondly, we ultrasonically visualized subsurface cellular details of thin tissue specimens with different modes (i.e., pulse and tone-burst wave modes) to obtain the highest quality ultrasonic images. The objective is to select the best mode for the future design of a future SAM for in-vivo examination. Thirdly, we developed a mathematical modeling technique based on an angular spectrum approach for improving image processing and comparing numerical to experimental results.

Paper Details

Date Published: 9 April 2010
PDF: 12 pages
Proc. SPIE 7650, Health Monitoring of Structural and Biological Systems 2010, 76502U (9 April 2010); doi: 10.1117/12.847649
Show Author Affiliations
C. Miyasaka, The Pennsylvania State Univ. (United States)
B. R. Tittmann, The Pennsylvania State Univ. (United States)
R. Tutwiler, The Pennsylvania State Univ. (United States)
Y. Tian, Univ. of Windsor (Canada)
E. Maeva, Univ. of Windsor (Canada)
D. Shum, Windsor Regional Hospital (Canada)

Published in SPIE Proceedings Vol. 7650:
Health Monitoring of Structural and Biological Systems 2010
Tribikram Kundu, Editor(s)

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