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Proceedings Paper

Hydrogel-based piezoresistive biochemical microsensors
Author(s): Margarita Guenther; Volker Schulz; Gerald Gerlach; Thomas Wallmersperger; Florian Solzbacher; Jules J. Magda; Prashant Tathireddy; Genyao Lin; Michael P. Orthner
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Paper Abstract

This work is motivated by a demand for inexpensive, robust and reliable biochemical sensors with high signal reproducibility and long-term-stable sensitivity, especially for medical applications. Micro-fabricated sensors can provide continuous monitoring and on-line control of analyte concentrations in ambient aqueous solutions. The piezoresistive biochemical sensor containing a special biocompatible polymer (hydrogel) with a sharp volume phase transition in the neutral physiological pH range near 7.4 can detect a specific analyte, for example glucose. Thereby the hydrogel-based biochemical sensors are useful for the diagnosis and monitoring of diabetes. The response of the glucosesensitive hydrogel was studied at different regimes of the glucose concentration change and of the solution supply. Sensor response time and accuracy with which a sensor can track gradual changes in glucose was estimated. Additionally, the influence of various recommended sterilization methods on the gel swelling properties and on the mechano-electrical transducer of the pH-sensors has been evaluated in order to choose the most optimal sterilization method for the implantable sensors. It has been shown that there is no negative effect of gamma irradiation with a dose of 25.7 kGy on the hydrogel sensitivity. In order to achieve an optimum between sensor signal amplitude and sensor response time, corresponding calibration and measurement procedures have been proposed and evaluated for the chemical sensors.

Paper Details

Date Published: 9 April 2010
PDF: 9 pages
Proc. SPIE 7642, Electroactive Polymer Actuators and Devices (EAPAD) 2010, 764227 (9 April 2010); doi: 10.1117/12.847373
Show Author Affiliations
Margarita Guenther, Technische Univ. Dresden (Germany)
Volker Schulz, Technische Univ. Dresden (Germany)
Gerald Gerlach, Technische Univ. Dresden (Germany)
Thomas Wallmersperger, Univ. Stuttgart (Germany)
Florian Solzbacher, The Univ. of Utah (United States)
Jules J. Magda, The Univ. of Utah (United States)
Prashant Tathireddy, The Univ. of Utah (United States)
Genyao Lin, The Univ. of Utah (United States)
Michael P. Orthner, The Univ. of Utah (United States)


Published in SPIE Proceedings Vol. 7642:
Electroactive Polymer Actuators and Devices (EAPAD) 2010
Yoseph Bar-Cohen, Editor(s)

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