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Proceedings Paper

Bypassing the blood-brain barrier: delivery of therapeutic agents by macrophages
Author(s): Henry Hirschberg; Seung-Kuk Baek; Young Jik Kwon; Chung-Ho Sun; Steen J. Madsen
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Paper Abstract

Introduction: Failure to eradicate infiltrating glioma cells using conventional treatment regimens results in tumor recurrence and is responsible for the dismal prognosis of patients with glioblastoma multiforme (GBM). This is due to the fact that these migratory cells are protected by the blood-brain barrier (BBB) and the blood brain tumor barrier (BBTB) which prevents the delivery of most anti-cancer agents. We have evaluated the ability of monocytes/macrophages (Mo/Ma) to cross the BBB in rats. This will permit access of anti-cancer agents such as nanoparticles to effectively target the infiltrating tumor cells, and potentially improve the treatment effectiveness for malignant gliomas. Materials and Methods: The infiltration of Mo/Ma into brain tumor spheroids in vitro was determined using fluorescent stained Mo/Ma. Tumors were also established in the brains of inbred rats and ALA-PDT was given 18 days following tumor induction. The degredation of the BBTB and quantification of the number of infiltrating Mo/Ma was examined on histological sections from removed brains. Results & Conclusion: PDT was highly effective in locally opening the BBTB and inducing macrophage migration into the irradiated portions of brain tumors.

Paper Details

Date Published: 2 March 2010
PDF: 5 pages
Proc. SPIE 7548, Photonic Therapeutics and Diagnostics VI, 75483Z (2 March 2010); doi: 10.1117/12.846958
Show Author Affiliations
Henry Hirschberg, Beckman Laser Institute and Medical Clinic, Univ. of California, Irvine (United States)
Univ. of Nevada, Las Vegas (United States)
Seung-Kuk Baek, Beckman Laser Institute and Medical Clinic, Univ. of California, Irvine (United States)
Young Jik Kwon, Univ. of California, Irvine (United States)
Chung-Ho Sun, Beckman Laser Institute and Medical Clinic, Univ. of California, Irvine (United States)
Steen J. Madsen, Beckman Laser Institute and Medical Clinic, Univ. of California, Irvine (United States)
Univ. of Nevada, Las Vegas (United States)


Published in SPIE Proceedings Vol. 7548:
Photonic Therapeutics and Diagnostics VI
Anita Mahadevan-Jansen; Andreas Mandelis; Brian Jet-Fei Wong; Nikiforos Kollias; Henry Hirschberg; Kenton W. Gregory; Reza S. Malek; E. Duco Jansen; Guillermo J. Tearney; Steen J. Madsen; Bernard Choi; Justus F. R. Ilgner; Haishan Zeng; Laura Marcu, Editor(s)

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