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Proceedings Paper

In vivo tumor imaging in mice with near-infrared: low density lipoprotein conjugates
Author(s): Xinyang Chen; Dawei Deng; Fei Liu; Hui Li; Zhiyu Qian; Yueqing Gu
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Paper Abstract

Near-infrared (NIR) fluorescence imaging possesses many advantages as an in vivo non-invasive optical imaging modality for studying diseases in preclinical models. In this study, low density lipoprotein(LDL) fraction was quickly isolated from human plasma by modified heparin-citrate precipitation method and then conjugated to near infrared fluorescence dye ICG-Der-02 with excitation and emission wavelengths at 760nm and 830nm, respectively. The conjugates LDL-ICG-Der-02 were intravenously injected into the mice bearing different tumor models. And real time series fluorescence tumor images at different intervals of post-injection were in vivo acquired by a self-built NIR reflectance fluorescence imaging system. Results demonstrated that LDL-ICG-Der-02 conjugates could efficiently target to the tumor sites that over-expressed LDL receptors and could be completely eliminated at last.

Paper Details

Date Published: 28 October 2009
PDF: 14 pages
Proc. SPIE 7519, Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009), 75190P (28 October 2009); doi: 10.1117/12.846899
Show Author Affiliations
Xinyang Chen, China Pharmaceutical Univ. (China)
Dawei Deng, China Pharmaceutical Univ. (China)
Fei Liu, China Pharmaceutical Univ. (China)
Hui Li, China Pharmaceutical Univ. (China)
Zhiyu Qian, Nanjing Univ. of Aeronautics and Astronautics (China)
Yueqing Gu, China Pharmaceutical Univ. (China)

Published in SPIE Proceedings Vol. 7519:
Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009)
Qingming Luo; Lihong V. Wang; Valery V. Tuchin; Pengcheng Li; Ling Fu, Editor(s)

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