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Proceedings Paper

In vivo operation of the Boston 15-channel wireless subretinal visual prosthesis
Author(s): Douglas B. Shire; Patrick Doyle; Shawn K. Kelly; Marcus D. Gingerich; Jinghua Chen; Stuart F. Cogan; William A. Drohan; Oscar Mendoza; Luke Theogarajan; John Wyatt; Joseph F. Rizzo
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Paper Abstract

This presentation concerns the engineering development of the Boston visual prosthesis for restoring useful vision to patients blind with degenerative retinal disease. A miniaturized, hermetically-encased, 15-channel wirelessly-operated retinal prosthetic was developed for implantation and pre-clinical studies in Yucatan mini-pig animal models. The prosthesis conforms to the eye and drives a microfabricated polyimide stimulating electrode array having sputtered iridium oxide electrodes. This array is implanted into the subretinal space using a specially-designed ab externo surgical technique; the bulk of the prosthesis is on the surface of the sclera. The implanted device includes a hermetic titanium case containing a 15-channel stimulator chip; secondary power/data receiving coils surround the cornea. Long-term in vitro pulse testing was also performed on the electrodes to ensure their stability over years of operation. Assemblies were first tested in vitro to verify wireless operation of the system in biological saline using a custom RF transmitter circuit and primary coils. Stimulation pulse strength, duration and frequency were programmed wirelessly using a computer with a custom graphical user interface. Operation of the retinal implant was verified in vivo in 3 minipigs for more than three months by measuring stimulus artifacts on the eye surface using contact lens electrodes.

Paper Details

Date Published: 4 February 2010
PDF: 8 pages
Proc. SPIE 7527, Human Vision and Electronic Imaging XV, 752705 (4 February 2010); doi: 10.1117/12.846745
Show Author Affiliations
Douglas B. Shire, Cornell Univ. (United States)
VA Ctr. for Innovative Visual Rehabilitation (United States)
Patrick Doyle, VA Ctr. for Innovative Visual Rehabilitation (United States)
Massachusetts Institute of Technology (United States)
Shawn K. Kelly, VA Ctr. for Innovative Visual Rehabilitation (United States)
Massachusetts Institute of Technology (United States)
Marcus D. Gingerich, Cornell Univ. (United States)
VA Ctr. for Innovative Visual Rehabilitation (United States)
Jinghua Chen, Massachusetts Eye and Ear Infirmary (United States)
Stuart F. Cogan, EIC Labs., Inc. (United States)
William A. Drohan, VA Ctr. for Innovative Visual Rehabilitation (United States)
Massachusetts Institute of Technology (United States)
Oscar Mendoza, Massachusetts Institute of Technology (United States)
Luke Theogarajan, Univ. of California, Santa Barbara (United States)
John Wyatt, Massachusetts Institute of Technology (United States)
Joseph F. Rizzo, VA Ctr. for Innovative Visual Rehabilitation (United States)
Massachusetts Eye and Ear Infirmary (United States)


Published in SPIE Proceedings Vol. 7527:
Human Vision and Electronic Imaging XV
Bernice E. Rogowitz; Thrasyvoulos N. Pappas, Editor(s)

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