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Proceedings Paper

In vivo PDT dosimetry: singlet oxygen emission and photosensitizer fluorescence
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Paper Abstract

Photodynamic therapy (PDT) is a light activated chemotherapy that is dependent on three parameters: photosensitizer (PS) concentration; oxygen concentration; and light dosage. Due to highly variable treatment response, the development of an accurate dosimeter to optimize PDT treatment outcome is an important requirement for practical applications. Singlet oxygen is an active species in PDT, and we are developing two instruments, an ultra-sensitive singlet oxygen point sensor and a 2D imager, with the goal of a real-time dosimeter for PDT researchers. The 2D imaging system can visualize spatial maps of both the singlet oxygen production and the location of the PS in a tumor during PDT. We have detected the production of singlet oxygen during PDT treatments with both in-vitro and in-vivo studies. Effects of photobleaching have also been observed. These results are promising for the development of the sensor as a real-time dosimeter for PDT which would be a valuable tool for PDT research and could lead to more effective treatment outcome. We summarize recent results in this paper.

Paper Details

Date Published: 4 March 2010
PDF: 7 pages
Proc. SPIE 7551, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIX, 75510F (4 March 2010); doi: 10.1117/12.846358
Show Author Affiliations
Seonkyung Lee, Physical Sciences Inc. (United States)
Kristin L. Galbally-Kinney, Physical Sciences Inc. (United States)
Brian A. Murphy, Physical Sciences Inc. (United States)
Steven J. Davis, Physical Sciences Inc. (United States)
Tayyaba Hasan, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)
Bryan Spring, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)
Yupeng Tu, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)
Brian W. Pogue, Dartmouth-Hitchcock Medical Ctr. (United States)
Martin E. Isabelle, Dartmouth-Hitchcock Medical Ctr. (United States)
Julia A. O'Hara, Dartmouth-Hitchcock Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 7551:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIX
David H. Kessel, Editor(s)

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