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Proceedings Paper

Photoacoustic characterization of human ovarian tissue
Author(s): Andres Aguirre; Yasaman Ardeshirpour; Mary M. Sanders; Molly Brewer; Quing Zhu
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Paper Abstract

Ovarian cancer has a five-year survival rate of only 30%, which represents the highest mortality of all gynecologic cancers. The reason for that is that the current imaging techniques are not capable of detecting ovarian cancer early. Therefore, new imaging techniques, like photoacoustic imaging, that can provide functional and molecular contrasts are needed for improving the specificity of ovarian cancer detection and characterization. Using a coregistered photoacoustic and ultrasound imaging system we have studied thirty-one human ovaries ex vivo, including normal and diseased. In order to compare the photoacoustic imaging results from all the ovaries, a new parameter using the RF data has been derived. The preliminary results show higher optical absorption for abnormal and malignant ovaries than for normal postmenopausal ones. To estimate the quantitative optical absorption properties of the ovaries, additional ultrasound-guided diffuse optical tomography images have been acquired. Good agreement between the two techniques has been observed. These results demonstrate the potential of a co-registered photoacoustic and ultrasound imaging system for the diagnosis of ovarian cancer.

Paper Details

Date Published: 23 February 2010
PDF: 7 pages
Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 75643G (23 February 2010); doi: 10.1117/12.845828
Show Author Affiliations
Andres Aguirre, Univ. of Connecticut (United States)
Yasaman Ardeshirpour, Univ. of Connecticut (United States)
Mary M. Sanders, Univ. of Connecticut Health Ctr. (United States)
Molly Brewer, Univ. of Connecticut Health Ctr. (United States)
Quing Zhu, Univ. of Connecticut (United States)

Published in SPIE Proceedings Vol. 7564:
Photons Plus Ultrasound: Imaging and Sensing 2010
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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