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Proceedings Paper

Volumetric breast density evaluation by ultrasound tomography and magnetic resonance imaging: a preliminary comparative study
Author(s): Lukasz Myc; Neb Duric; Peter Littrup; Cuiping Li; Bryan Ranger; Jessica Lupinacci; Steven Schmidt; Olsi Rama; Lisa Bey-Knight
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Paper Abstract

Since a 1976 study by Wolfe, high breast density has gained recognition as a factor strongly correlating with an increased incidence of breast cancer. These observations have led to mammographic density being designated a "risk factor" for breast cancer. Clinically, the exclusive reliance on mammography for breast density measurement has forestalled the inclusion of breast density into statistical risk models. This exclusion has in large part been due to the ionizing radiation associated with the method. Additionally, the use of mammography as valid tool for measuring a three dimensional characteristic (breast density) has been criticized for its prima facie incongruity. These shortfalls have prompted MRI studies of breast density as an alternative three-dimensional method of assessing breast density. Although, MRI is safe and can be used to measure volumetric density, its cost has prohibited its use in screening. Here, we report that sound speed measurements using a prototype ultrasound tomography device have potential for use as surrogates for breast density measurement. Accordingly, we report a strong positive linear correlation between volume-averaged sound speed of the breast and percent glandular tissue volume as assessed by MR.

Paper Details

Date Published: 12 March 2010
PDF: 8 pages
Proc. SPIE 7629, Medical Imaging 2010: Ultrasonic Imaging, Tomography, and Therapy, 76290N (12 March 2010); doi: 10.1117/12.845648
Show Author Affiliations
Lukasz Myc, Karmanos Cancer Institute, Wayne State Univ. (United States)
Neb Duric, Karmanos Cancer Institute, Wayne State Univ. (United States)
Peter Littrup, Karmanos Cancer Institute, Wayne State Univ. (United States)
Cuiping Li, Karmanos Cancer Institute, Wayne State Univ. (United States)
Bryan Ranger, Karmanos Cancer Institute, Wayne State Univ. (United States)
Jessica Lupinacci, Karmanos Cancer Institute, Wayne State Univ. (United States)
Steven Schmidt, Karmanos Cancer Institute, Wayne State Univ. (United States)
Olsi Rama, Karmanos Cancer Institute, Wayne State Univ. (United States)
Lisa Bey-Knight, Karmanos Cancer Institute, Wayne State Univ. (United States)


Published in SPIE Proceedings Vol. 7629:
Medical Imaging 2010: Ultrasonic Imaging, Tomography, and Therapy
Jan D'hooge; Stephen A. McAleavey, Editor(s)

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