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Proceedings Paper

In-vivo imaging results with ultrasound tomography: report on an ongoing study at the Karmanos Cancer Institute
Author(s): Nebojsa Duric; Peter Littrup; Priti Chandiwala-Mody; Cuiping Li; Steven Schmidt; Lukasz Myc; Olsi Rama; Lisa Bey-Knight; Jessica Lupinacci; Bryan Ranger; Amy Szczepanski; Erik West
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Paper Abstract

Our laboratory has focused on the development of ultrasound tomography (UST) for breast imaging. To that end we have been developing and testing a clinical prototype in the Karmanos Cancer Institute's (KCI) breast center. The development of our prototype has been guided by clinical feedback from data accumulated from over 300 patients recruited over the last 4 years. Our techniques generate whole breast reflection images as well as images of the acoustic parameters of sound speed and attenuation. The combination of these images reveals major breast anatomy, including fat, parenchyma, fibrous stroma and masses. Fusion imaging, utilizing thresholding, is shown to visualize mass characterization and facilitates separation of cancer from benign masses. These results indicate that operator-independent whole-breast imaging and the detection and characterization of cancerous breast masses are feasible using acoustic tomography techniques. Analyses of the prototype images suggests that we can detect the variety of mass attributes noted by current ultrasound-BIRADS criteria, such as mass shape, acoustic mass properties and architecture of the tumor environment. These attributes help quantify current BIRADS criteria (e.g. "shadowing" or high attenuation) and provide greater possibilities for defining a unique signature of cancer. The potential for UST to detect and characterize breast masses was quantified using UST measurements of 86 masses from the most recent cohort of patients imaged with the latest version of our prototype. Our preliminary results suggest that the development of a formal predictive model, in support of larger future trials, is warranted.

Paper Details

Date Published: 12 March 2010
PDF: 9 pages
Proc. SPIE 7629, Medical Imaging 2010: Ultrasonic Imaging, Tomography, and Therapy, 76290M (12 March 2010); doi: 10.1117/12.845646
Show Author Affiliations
Nebojsa Duric, Karmanos Cancer Institute (United States)
Peter Littrup, Karmanos Cancer Institute (United States)
Priti Chandiwala-Mody, Karmanos Cancer Institute (United States)
Cuiping Li, Karmanos Cancer Institute (United States)
Steven Schmidt, Karmanos Cancer Institute (United States)
Lukasz Myc, Karmanos Cancer Institute (United States)
Olsi Rama, Karmanos Cancer Institute (United States)
Lisa Bey-Knight, Karmanos Cancer Institute (United States)
Jessica Lupinacci, Karmanos Cancer Institute (United States)
Bryan Ranger, Karmanos Cancer Institute (United States)
Amy Szczepanski, Karmanos Cancer Institute (United States)
Erik West, Karmanos Cancer Institute (United States)

Published in SPIE Proceedings Vol. 7629:
Medical Imaging 2010: Ultrasonic Imaging, Tomography, and Therapy
Jan D'hooge; Stephen A. McAleavey, Editor(s)

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