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Proceedings Paper

Patient-specific radiation dose and cancer risk estimation in pediatric chest CT: a study in 30 patients
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Paper Abstract

Radiation-dose awareness and optimization in CT can greatly benefit from a dosereporting system that provides radiation dose and cancer risk estimates specific to each patient and each CT examination. Recently, we reported a method for estimating patientspecific dose from pediatric chest CT. The purpose of this study is to extend that effort to patient-specific risk estimation and to a population of pediatric CT patients. Our study included thirty pediatric CT patients (16 males and 14 females; 0-16 years old), for whom full-body computer models were recently created based on the patients' clinical CT data. Using a validated Monte Carlo program, organ dose received by the thirty patients from a chest scan protocol (LightSpeed VCT, 120 kVp, 1.375 pitch, 40-mm collimation, pediatric body scan field-of-view) was simulated and used to estimate patient-specific effective dose. Risks of cancer incidence were calculated for radiosensitive organs using gender-, age-, and tissue-specific risk coefficients and were used to derive patientspecific effective risk. The thirty patients had normalized effective dose of 3.7-10.4 mSv/100 mAs and normalized effective risk of 0.5-5.8 cases/1000 exposed persons/100 mAs. Normalized lung dose and risk of lung cancer correlated strongly with average chest diameter (correlation coefficient: r = -0.98 to -0.99). Normalized effective risk also correlated strongly with average chest diameter (r = -0.97 to -0.98). These strong correlations can be used to estimate patient-specific dose and risk prior to or after an imaging study to potentially guide healthcare providers in justifying CT examinations and to guide individualized protocol design and optimization.

Paper Details

Date Published: 22 March 2010
PDF: 10 pages
Proc. SPIE 7622, Medical Imaging 2010: Physics of Medical Imaging, 76221J (22 March 2010); doi: 10.1117/12.845491
Show Author Affiliations
Xiang Li, Duke Univ. (United States)
Ehsan Samei, Duke Univ. (United States)
W. Paul Segars, Duke Univ. (United States)
Gregory M. Sturgeon, Duke Univ. (United States)
The Univ. of North Carolina at Chapel Hill (United States)
James G. Colsher, Duke Univ. (United States)
Donald P. Frush, Duke Univ. (United States)

Published in SPIE Proceedings Vol. 7622:
Medical Imaging 2010: Physics of Medical Imaging
Ehsan Samei; Norbert J. Pelc, Editor(s)

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