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Proceedings Paper

Application of a modified regularization procedure for estimating oxygen tension in large retinal blood vessels
Author(s): Isa Yildirim; Rashid Ansari; I. Samil Yetik; Mahnaz Shahidi
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Paper Abstract

Phosphorescence lifetime measurement based on a frequency domain approach is used to estimate oxygen tension in large retinal blood vessels. The classical least squares (LS) estimation was initially used to determine oxygen tension indirectly from intermediate variables. A spatial regularized least squares (RLS) method was later proposed to reduce the high variance of oxygen tension estimated by LS method. In this paper, we provide a solution using a modified RLS (MRLS) approach that utilizes prior knowledge about retinal vessels oxygenation based on expected oxygen tension values in retinal arteries and veins. The performance of MRLS method was evaluated in simulated and experimental data by determining the bias, variance, and mean absolute error (MAE) of oxygen tension measurements and comparing these parameters with those derived with the use of LS and RLS methods.

Paper Details

Date Published: 13 March 2010
PDF: 6 pages
Proc. SPIE 7623, Medical Imaging 2010: Image Processing, 76233E (13 March 2010); doi: 10.1117/12.845468
Show Author Affiliations
Isa Yildirim, Univ. of Illinois at Chicago (United States)
Istanbul Teknik Üniv. (Turkey)
Rashid Ansari, Univ. of Illinois at Chicago (United States)
I. Samil Yetik, Illinois Institute of Technology (United States)
Mahnaz Shahidi, Univ. of Illinois at Chicago (United States)


Published in SPIE Proceedings Vol. 7623:
Medical Imaging 2010: Image Processing
Benoit M. Dawant; David R. Haynor, Editor(s)

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