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Proceedings Paper

Label-free and dynamic detection of biomolecular interactions based on surface plasmon resonance imaging for high-throughput microarray applications
Author(s): Shengyi Chen; Qiang Li; Tao Deng; Guoliang Huang
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Paper Abstract

We combined SPRi and protein microarray to build a system for dynamic monitoring of interaction between biomolecules. With this system, we achieved label-free, real-time and automatic detection of specific antigen-antibody interactions. Because protein microarray can be high-throughput, and SPRi is able to achieve real-time and simultaneous monitoring of each probe on the microarray, our system has great potential to realize large-scale and dynamic tracing interactions among biomolecules, thus facilitating drug discovery, molecular diagnostics, signal pathway studies and many other fields.

Paper Details

Date Published: 29 October 2009
PDF: 8 pages
Proc. SPIE 7519, Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009), 75190R (29 October 2009); doi: 10.1117/12.845440
Show Author Affiliations
Shengyi Chen, Tsinghua Univ. School of Medicine (China)
National Engineering Research Ctr. for Beijing Biochip Technology (China)
Qiang Li, Tsinghua Univ. School of Medicine (China)
National Engineering Research Ctr. for Beijing Biochip Technology (China)
Tao Deng, Tsinghua Univ. School of Medicine (China)
National Engineering Research Ctr. for Beijing Biochip Technology (China)
Guoliang Huang, Tsinghua Univ. School of Medicine (China)
National Engineering Research Ctr. for Beijing Biochip Technology (China)


Published in SPIE Proceedings Vol. 7519:
Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009)

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