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Proceedings Paper

Novel nano drug delivery systems for hepatic tumor
Author(s): Yu Cao; Jing Liu; Hong Ma; Jing Bai; Chao Qi
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Paper Abstract

The adriamycin and galactose was grafted to dextran. The novel nanopartcile drug delivery system (DDS) was prepared from the chemical modified polysaccharide by the dialysis. The content of the ADR moiety in the polymeric-drug conjugate was about 2 mol%. The size and morphology of prepared nanoparticles were characterized using dynamic light scattering and transmission electron microscope. The results showed that the nanoparticles were spherical and their size was less than 200 nm. In vitro cytotoxicity of the nanoparticles was tested by the MTT assay. The nano DDS has similar cytotoxicity as free adriamycin for incubation with HepG2 cells. In contrast, for the incubation with Hela cells of the DDS, there was no signicant cytotoxicity change.

Paper Details

Date Published: 28 October 2009
PDF: 10 pages
Proc. SPIE 7519, Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009), 751912 (28 October 2009); doi: 10.1117/12.844928
Show Author Affiliations
Yu Cao, Central China Normal Univ. (China)
Jing Liu, Central China Normal Univ. (China)
Hong Ma, Central China Normal Univ. (China)
Jing Bai, Central China Normal Univ. (China)
Chao Qi, Central China Normal Univ. (China)

Published in SPIE Proceedings Vol. 7519:
Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009)
Qingming Luo; Lihong V. Wang; Valery V. Tuchin; Pengcheng Li; Ling Fu, Editor(s)

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