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Proceedings Paper

Fundus image registration for vestibularis research
Author(s): Vamsi K. Ithapu; Armin Fritsche; Ariane Oppelt; Martin Westhofen M.D.; Thomas M. Deserno
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Paper Abstract

In research on vestibular nerve disorders, fundus images of both left and right eyes are acquired systematically to precisely assess the rotation of the eye ball that is induced by the rotation of entire head. The measurement is still carried out manually. Although various methods have been proposed for medical image registration, robust detection of rotation especially in images with varied quality in terms of illumination, aberrations, blur and noise still is challenging. This paper evaluates registration algorithms operating on different levels of semantics: (i) data-based using Fourier transform and log polar maps; (ii) point-based using scaled image feature transform (SIFT); (iii) edge-based using Canny edge maps; (iv) object-based using matched filters for vessel detection; (v) scene-based detecting papilla and macula automatically and (vi) manually by two independent medical experts. For evaluation, a database of 22 patients is used, where each of left and right eye images is captured in upright head position and in lateral tilt of ±200. For 66 pairs of images (132 in total), the results are compared with ground truth, and the performance measures are tabulated. Best correctness of 89.3% were obtained using the pixel-based method and allowing 2.5° deviation from the manual measures. However, the evaluation shows that for applications in computer-aided diagnosis involving a large set of images with varied quality, like in vestibularis research, registration methods based on a single level of semantics are not sufficiently robust. A multi-level semantics approach will improve the results since failure occur on different images.

Paper Details

Date Published: 9 March 2010
PDF: 10 pages
Proc. SPIE 7624, Medical Imaging 2010: Computer-Aided Diagnosis, 76243E (9 March 2010); doi: 10.1117/12.844475
Show Author Affiliations
Vamsi K. Ithapu, Indian Institute of Technology Guwahati (India)
Armin Fritsche, RWTH Aachen (Germany)
Ariane Oppelt, RWTH Aachen (Germany)
Martin Westhofen M.D., RWTH Aachen (Germany)
Thomas M. Deserno, RWTH Aachen (Germany)

Published in SPIE Proceedings Vol. 7624:
Medical Imaging 2010: Computer-Aided Diagnosis
Nico Karssemeijer; Ronald M. Summers, Editor(s)

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