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Proceedings Paper

System matrix for OSEM SPECT with attenuation compensation in mesh domain
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Paper Abstract

The purpose of this study was to develop and implement an accurate and computationally efficient method for determination of the mesh-domain ssssssystem matrix including attenuation compensation for Ordered Subsets Expectation Maximization (OSEM) Single Photon Emission Computed Tomography (SPECT). The mesh-domain system matrix elements were estimated by first partitioning the object domain into strips parallel to detector face and with width not exceeding the size of a detector unit. This was followed by approximating the integration over the strip/mesh-element union. This approximation is product of: (i) strip width, (ii) intersection length of a ray central to strip with a mesh element, and (iii) the response and expansion function evaluated at midpoint of the intersection length. Reconstruction was performed using OSEM without regularization and with exact knowledge of the attenuation map. The method was evaluated using synthetic SPECT data generated using SIMIND Monte Carlo simulation software. Comparative quantitative and qualitative analysis included: bias, variance, standard deviation and line-profiles within three different regions of interest. We found that no more than two divisions per detector bin were needed for good quality reconstructed images when using a high resolution mesh.

Paper Details

Date Published: 23 March 2010
PDF: 7 pages
Proc. SPIE 7622, Medical Imaging 2010: Physics of Medical Imaging, 76225B (23 March 2010); doi: 10.1117/12.844427
Show Author Affiliations
Levon Vogelsang, Syracuse Univ. (United States)
Andrzej Krol, SUNY Upstate Medical Univ. (United States)
Syracuse Univ. (United States)
David H. Feiglin, SUNY Upstate Medical Univ. (United States)
Syracuse Univ. (United States)
Edward Lipson, Syracuse Univ. (United States)
SUNY Upstate Medical Univ. (United States)


Published in SPIE Proceedings Vol. 7622:
Medical Imaging 2010: Physics of Medical Imaging
Ehsan Samei; Norbert J. Pelc, Editor(s)

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