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Proceedings Paper

Automatic classification of pathological myopia in retinal fundus images using PAMELA
Author(s): Jiang Liu; Damon W. K. Wong; Ngan Meng Tan; Zhuo Zhang; Shijian Lu; Joo Hwee Lim; Huiqi Li; Seang Mei Saw; Louis Tong; Tien Yin Wong
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Paper Abstract

Pathological myopia is the seventh leading cause of blindness. We introduce a framework based on PAMELA (PAthological Myopia dEtection through peripapilLary Atrophy) for the detection of pathological myopia from fundus images. The framework consists of a pre-processing stage which extracts a region of interest centered on the optic disc. Subsequently, three analysis modules focus on detecting specific visual indicators. The optic disc tilt ratio module gives a measure of the axial elongation of the eye through inference from the deformation of the optic disc. In the texturebased ROI assessment module, contextual knowledge is used to demarcate the ROI into four distinct, clinically-relevant zones in which information from an entropy transform of the ROI is analyzed and metrics generated. In particular, the preferential appearance of peripapillary atrophy (PPA) in the temporal zone compared to the nasal zone is utilized by calculating ratios of the metrics. The PPA detection module obtains an outer boundary through a level-set method, and subtracts this region against the optic disc boundary. Temporal and nasal zones are obtained from the remnants to generate associated hue and color values. The outputs of the three modules are used as in a SVM model to determine the presence of pathological myopia in a retinal fundus image. Using images from the Singapore Eye Research Institute, the proposed framework reported an optimized accuracy of 90% and a sensitivity and specificity of 0.85 and 0.95 respectively, indicating promise for the use of the proposed system as a screening tool for pathological myopia.

Paper Details

Date Published: 9 March 2010
PDF: 8 pages
Proc. SPIE 7624, Medical Imaging 2010: Computer-Aided Diagnosis, 76240G (9 March 2010); doi: 10.1117/12.844122
Show Author Affiliations
Jiang Liu, A*STAR Institute for Infocomm Research (Singapore)
Damon W. K. Wong, A*STAR Institute for Infocomm Research (Singapore)
Ngan Meng Tan, A*STAR Institute for Infocomm Research (Singapore)
Zhuo Zhang, A*STAR Institute for Infocomm Research (Singapore)
Shijian Lu, A*STAR Institute for Infocomm Research (Singapore)
Joo Hwee Lim, A*STAR Institute for Infocomm Research (Singapore)
Huiqi Li, A*STAR Institute for Infocomm Research (Singapore)
Seang Mei Saw, National Univ. of Singapore (Singapore)
Louis Tong, Singapore National Eye Ctr. (Singapore)
Tien Yin Wong, National Univ. of Singapore (Singapore)
Singapore Eye Research Institute (Singapore)

Published in SPIE Proceedings Vol. 7624:
Medical Imaging 2010: Computer-Aided Diagnosis
Nico Karssemeijer; Ronald M. Summers, Editor(s)

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