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Proceedings Paper

3D bone mineral density distribution and shape reconstruction of the proximal femur from a single simulated DXA image: an in vitro study
Author(s): Tristan Whitmarsh; Ludovic Humbert; Mathieu De Craene; Luis M. del Río Barquero; Karl Fritscher; Rainer Schubert; Felix Eckstein; Thomas Link; Alejandro F. Frangi
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Paper Abstract

Area Bone Mineral Density (aBMD) measured by Dual-energy X-ray Absorptiometry (DXA) is an established criterion in the evaluation of hip fracture risk. The evaluation from these planar images, however, is limited to 2D while it has been shown that proper 3D assessment of both the shape and the Bone Mineral Density (BMD) distribution improves the fracture risk estimation. In this work we present a method to reconstruct both the 3D bone shape and 3D BMD distribution of the proximal femur from a single DXA image. A statistical model of shape and a separate statistical model of the BMD distribution were automatically constructed from a set of Quantitative Computed Tomography (QCT) scans. The reconstruction method incorporates a fully automatic intensity based 3D-2D registration process, maximizing the similarity between the DXA and a digitally reconstructed radiograph of the combined model. For the construction of the models, an in vitro dataset of QCT scans of 60 anatomical specimens was used. To evaluate the reconstruction accuracy, experiments were performed on simulated DXA images from the QCT scans of 30 anatomical specimens. Comparisons between the reconstructions and the same subject QCT scans showed a mean shape accuracy of 1.2mm, and a mean density error of 81mg/cm3. The results show that this method is capable of accurately reconstructing both the 3D shape and 3D BMD distribution of the proximal femur from DXA images used in clinical routine, potentially improving the diagnosis of osteoporosis and fracture risk assessments at a low radiation dose and low cost.

Paper Details

Date Published: 13 March 2010
PDF: 9 pages
Proc. SPIE 7623, Medical Imaging 2010: Image Processing, 76234U (13 March 2010); doi: 10.1117/12.844110
Show Author Affiliations
Tristan Whitmarsh, Univ. Pompeu Fabra (Spain)
Networking Research Ctr. on Bioengineering (Spain)
Ludovic Humbert, Univ. Pompeu Fabra (Spain)
Networking Research Ctr. on Bioengineering (Spain)
Mathieu De Craene, Networking Research Ctr. on Bioengineering (Spain)
Univ. Pompeu Fabra (Spain)
Luis M. del Río Barquero, CETIR Ctr. Mèdic (Spain)
Karl Fritscher, Institute for Biomedical Image Analysis, UMIT (Austria)
Rainer Schubert, Institute for Biomedical Image Analysis, UMIT (Austria)
Felix Eckstein, Paracelsus Medical Univ. (Austria)
Thomas Link, Univ. of California, San Francisco (United States)
Alejandro F. Frangi, Univ. Pompeu Fabra (Spain)
Networking Research Ctr. on Bioengineering (Spain)
Institució Catalana de Recerca i Estudis Avançats (Spain)


Published in SPIE Proceedings Vol. 7623:
Medical Imaging 2010: Image Processing
Benoit M. Dawant; David R. Haynor, Editor(s)

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