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Proceedings Paper

Variation compensation and analysis on diaphragm curvature analysis for emphysema quantification on whole lung CT scans
Author(s): Brad M. Keller; Anthony P. Reeves; R. Graham Barr; David F. Yankelevitz; Claudia I. Henschke
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Paper Abstract

CT scans allow for the quantitative evaluation of the anatomical bases of emphysema. Recently, a non-density based geometric measurement of lung diagphragm curvature has been proposed as a method for the quantification of emphysema from CT. This work analyzes variability of diaphragm curvature and evaluates the effectiveness of a compensation methodology for the reduction of this variability as compared to emphysema index. Using a dataset of 43 scan-pairs with less than a 100 day time-interval between scans, we find that the diaphragm curvature had a trend towards lower overall variability over emphysema index (95% CI:-9.7 to + 14.7 vs. -15.8 to +12.0), and that the variation of both measures was reduced after compensation. We conclude that the variation of the new measure can be considered comparable to the established measure and the compensation can reduce the apparent variation of quantitative measures successfully.

Paper Details

Date Published: 9 March 2010
PDF: 7 pages
Proc. SPIE 7624, Medical Imaging 2010: Computer-Aided Diagnosis, 762432 (9 March 2010); doi: 10.1117/12.844012
Show Author Affiliations
Brad M. Keller, Cornell Univ. (United States)
Anthony P. Reeves, Cornell Univ. (United States)
R. Graham Barr, Columbia Univ. (United States)
David F. Yankelevitz, Weill Cornell Medical College (United States)
Claudia I. Henschke, Weill Cornell Medical College (United States)


Published in SPIE Proceedings Vol. 7624:
Medical Imaging 2010: Computer-Aided Diagnosis
Nico Karssemeijer; Ronald M. Summers, Editor(s)

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