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Proceedings Paper

Automated 3D segmentation of intraretinal layers from optic nerve head optical coherence tomography images
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Paper Abstract

Optical coherence tomography (OCT), being a noninvasive imaging modality, has begun to find vast use in the diagnosis and management of ocular diseases such as glaucoma, where the retinal nerve fiber layer (RNFL) has been known to thin. Furthermore, the recent availability of the considerably larger volumetric data with spectral-domain OCT has increased the need for new processing techniques. In this paper, we present an automated 3-D graph-theoretic approach for the segmentation of 7 surfaces (6 layers) of the retina from 3-D spectral-domain OCT images centered on the optic nerve head (ONH). The multiple surfaces are detected simultaneously through the computation of a minimum-cost closed set in a vertex-weighted graph constructed using edge/regional information, and subject to a priori determined varying surface interaction and smoothness constraints. The method also addresses the challenges posed by presence of the large blood vessels and the optic disc. The algorithm was compared to the average manual tracings of two observers on a total of 15 volumetric scans, and the border positioning error was found to be 7.25 ± 1.08 μm and 8.94 ± 3.76 μm for the normal and glaucomatous eyes, respectively. The RNFL thickness was also computed for 26 normal and 70 glaucomatous scans where the glaucomatous eyes showed a significant thinning (p < 0.01, mean thickness 73.7 ± 32.7 μm in normal eyes versus 60.4 ± 25.2 μm in glaucomatous eyes).

Paper Details

Date Published: 9 March 2010
PDF: 12 pages
Proc. SPIE 7626, Medical Imaging 2010: Biomedical Applications in Molecular, Structural, and Functional Imaging, 76260U (9 March 2010); doi: 10.1117/12.843928
Show Author Affiliations
Bhavna J. Antony, The Univ. of Iowa (United States)
Michael D. Abràmoff, The Univ. of Iowa (United States)
Veterans Administration Medical Ctr., Iowa City (United States)
Kyungmoo Lee, The Univ. of Iowa (United States)
Pavlina Sonkova, The Univ. of Iowa (United States)
Priya Gupta, The Univ. of Iowa (United States)
Young Kwon, The Univ. of Iowa (United States)
Meindert Niemeijer, Univ. Medical Ctr. Utrecht (Netherlands)
Zhihong Hu, The Univ. of Iowa (United States)
Mona K. Garvin, The Univ. of Iowa (United States)

Published in SPIE Proceedings Vol. 7626:
Medical Imaging 2010: Biomedical Applications in Molecular, Structural, and Functional Imaging
Robert C. Molthen; John B. Weaver, Editor(s)

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