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Proceedings Paper

Noise filtering in thin-slice 4D cerebral CT perfusion scans
Author(s): Adriënne Mendrik; Evert-jan Vonken; Jan-Willem Dankbaar; Mathias Prokop; Bram van Ginneken
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Paper Abstract

Patients suffering from cerebral ischemia or subarachnoid hemorrhage, undergo a 4D (3D+time) CT Perfusion (CTP) scan to assess the cerebral perfusion and a CT Angiography (CTA) scan to assess the vasculature. The aim of our research is to extract the vascular information from the CTP scan. This requires thin-slice CTP scans that suffer from a substantial amount of noise. Therefore noise reduction is an important prerequisite for further analysis. So far, the few noise filtering methods for 4D datasets proposed in literature deal with the temporal dimension as a 4th dimension similar to the 3 spatial dimensions, mixing temporal and spatial intensity information. We propose a bilateral noise reduction method based on time-intensity profile similarity (TIPS), which reduces noise while preserving temporal intensity information. TIPS was compared to 4D bilateral filtering on 10 patient CTP scans and, even though TIPS bilateral filtering is much faster, it results in better vessel visibility and higher image quality ranking (observer study) than 4D bilateral filtering.

Paper Details

Date Published: 12 March 2010
PDF: 7 pages
Proc. SPIE 7623, Medical Imaging 2010: Image Processing, 76230N (12 March 2010); doi: 10.1117/12.843813
Show Author Affiliations
Adriënne Mendrik, Univ. Medical Ctr. Utrecht (Netherlands)
Evert-jan Vonken, Univ. Medical Ctr. Utrecht (Netherlands)
Jan-Willem Dankbaar, Univ. Medical Ctr. Utrecht (Netherlands)
Mathias Prokop, Univ. Medical Ctr. Utrecht (Netherlands)
Bram van Ginneken, Univ. Medical Ctr. Utrecht (Netherlands)

Published in SPIE Proceedings Vol. 7623:
Medical Imaging 2010: Image Processing
Benoit M. Dawant; David R. Haynor, Editor(s)

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