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Proceedings Paper

Quantitative estimation of IL-6 in serum/plasma samples using a rapid and cost-effective fiber optic dip-probe
Author(s): Chun-Wei Wang; Upender Manne; Vishnu B. Reddy; Rakesh Kapoor
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Paper Abstract

A rapid and cost-effective combination tapered fiber-optic biosensor (CTFOB) dip-probe was used for quantitative estimation of interleukin (IL)-6 in serum/plasma samples. Sandwich immunoassay was used as the detection technique. Probes could successfully detect presence of IL-6 in two serum samples, non-neoplastic autoimmune patient (lupus) sample and lymphoma patient sample. The estimated amount of IL-6 in lupus patient sample was 4.8 ± 0.9 pM and in lymphoma patient sample was 2 ± 1 pM. It is demonstrated that the developed CTFOB dip-probe is capable of quantitative estimation of proteins in serum/plasma samples with high specificity.

Paper Details

Date Published: 24 February 2010
PDF: 5 pages
Proc. SPIE 7559, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications X, 75590G (24 February 2010); doi: 10.1117/12.843807
Show Author Affiliations
Chun-Wei Wang, The Univ. of Alabama at Birmingham (United States)
Upender Manne, The Univ. of Alabama at Birmingham (United States)
Vishnu B. Reddy, The Univ. of Alabama at Birmingham (United States)
Rakesh Kapoor, The Univ. of Alabama at Birmingham (United States)


Published in SPIE Proceedings Vol. 7559:
Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications X
Israel Gannot, Editor(s)

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